Water → 4-[1-Hydroxycyclohex1-yl-1-(imidazolyl)methyl]benzonitrile

HRID 35906Notes

Reaction equation

HRID 35906 reaction equation
[NH:1]1[CH:5]=[CH:4][N:3]=[C:2]1[CH2:6][C:7]1[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=1.C([N-]C(C)C)(C)C.[Li+].[C:23]1(=[O:29])[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1.O>O1CCCC1.C(OCC)(=O)C>[OH:29][C:23]1([CH:6]([C:7]2[CH:14]=[CH:13][C:10]([C:11]#[N:12])=[CH:9][CH:8]=2)[C:2]2[NH:1][CH:5]=[CH:4][N:3]=2)[CH2:28][CH2:27][CH2:26][CH2:25][CH2:24]1

Participants

7

Reactant 4

HCID 962WaterHCID 7967CyclohexanoneHCID 2724682Lithium diisopropylamideHCID 111481024-(1-Imidazolylmethyl)benzonitrile

Product 1

HCID 199395204-[1-Hydroxycyclohex1-yl-1-(imidazolyl)methyl]benzonitrileYield 96.1%

Reagents, catalysts & solvents 2

HCID 8028TetrahydrofuranSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

1.83 g of 4-[1-(imidazolyl)methyl]benzonitrile is dissolved in 50 ml of tetrahydrofuran and combined at -50° with 7.3 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran; the mixture is stirred for 0.5 hour, further stirred with 1.05 g of cyclohexanone for 1 hour at -60°, and heated to 25°. Then water is added, the mixture is diluted with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, yielding 2.7 g of crude 4-[1-hydroxycyclohex1-yl-1-(imidazolyl)methyl]benzonitrile.

Workup

  1. temperatureheated to 25°
  2. washwashed neutral with water
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated to dryness under vacuum

Sources & evidence

ORD record
ord-d56b74125c8e41328261b4664e4fa6b5
Source dataset
uspto-grants-1995_05
Patent number
US05411982

Reaction notes

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