反应详情

5.0 g of 4-[1- (imidazolyl)methyl]benzonitrile is dissolved in 150 ml of tetrahydrofuran and combined at -50° with 20 ml of 1.5-molar solution of lithium diisopropylamide in tetrahydrofuran, stirred for 0.5 hour at -60° combined with 2 5 g of cyclopentanone, further stirred for 1 hour, and heated to 25°. Then water is added to the mixture, the latter is diluted with ethyl acetate, washed neutral with water, dried over sodium sulfate, and concentrated to dryness under vacuum, yielding 6.9 g of crude 4-[1-hydroxycyclopent-1-yl-1-(imidazolyl)methyl]benzonitrile.

1. stirringfurther stirred for 1 hour
2. temperatureheated to 25°
3. washwashed neutral with water
4. dry with materialdried over sodium sulfate
5. concentrationconcentrated to dryness under vacuum