Benzoyl isothiocyanate → HCID 15135525, compound

HRID 359531Notes

Reaction equation

HRID 359531 reaction equation
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][CH3:7])=[O:5].[C:12]([N:20]=[C:21]=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>CCOCC>[C:12]([NH:20][C:21]([NH:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1[C:4]([NH:6][CH3:7])=[O:5])=[S:22])(=[O:19])[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1

Participants

4

Reactant 2

HCID 68284Benzoyl isothiocyanateHCID 3080722-Amino-N-methylbenzamide

Product 1

HCID 15135525HCID 15135525, compoundYield 87.9%

Reagents, catalysts & solvents 1

HCID 3283Diethyl EtherSolvent2×

Procedure

To a stirred mixture of 12 g of 2-amino-N-methylbenzamide and 200 ml of ether was added dropwise, a solution of 13.1 g of benzoyl isothiocyanate in 100 ml of ether over 30 minutes. The solid was collected, giving 22 g of the desired product as cream-colored crystals, mp 203°-205° C. (dec.).

Workup

  1. additionwas added dropwise
  2. customThe solid was collected

Sources & evidence

ORD record
ord-612126bdaac440fc8e5787c1f62b3aec
Source dataset
uspto-grants-1991_03
Patent number
US05001157

Reaction notes

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