Anisole → HCID 178503585, compound

HRID 359928Notes

Reaction equation

HRID 359928 reaction equation
[CH3:1][C:2]1[CH:3]=[CH:4][C:5]2[C:6](=[CH:11][CH:12]=1)[N:7]=[C:8](C)[N:9]=2.[C:13]1(OC)C=CC=CC=1.[F:21][C:22]([F:29])([F:28])[S:23]([O:26]C)(=[O:25])=[O:24]>C(OCC)(=O)C>[F:21][C:22]([F:29])([F:28])[S:23]([O-:26])(=[O:25])=[O:24].[CH3:13][N:7]1[C:6]2=[CH:11][CH:12]=[C:2]([CH3:1])[CH:3]=[CH:4][C:5]2=[NH+:9][CH:8]1[S:23][CH3:22]

Participants

5

Reactant 3

HCID 7519AnisoleHCID 9526Methyl triflateHCID 20064366HCID 20064366, compound

Product 1

HCID 178503585HCID 178503585, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

27 g of 6-methyl-2-methylcycloheptimidazole was added to 100 ml of anisole and stirred under cooling with ice. Next, 28 g of methyl trifluoromethanesulfonate was dropwise added and further everything was stirred under cooling with ice. After everything was stirred for 1 hour at room temperature, 200 ml of ethyl acetate was added, and the crystals precipitated were separated by filtration and dried.

Workup

  1. temperatureunder cooling with ice
  2. stirringfurther everything was stirred
  3. temperatureunder cooling with ice
  4. stirringAfter everything was stirred for 1 hour at room temperature
  5. customthe crystals precipitated
  6. customwere separated by filtration
  7. customdried

Sources & evidence

ORD record
ord-372a23129d09481db7728c198ba66752
Source dataset
uspto-grants-1991_03
Patent number
US05003077

Reaction notes

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