反应详情

To a solution of 5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine (10 g, 39 mmol) in DMF (70 mL) at room temperature was added NaH (1.3 g of an 80% dispersion, 43 mmol). After 20 min benzyl bromide (5.15 mL, 43 mmol) was added and the reaction was stirred for 16 h. The mixture was poured onto 500 g of ice and the solid residue was filtered, washed with water and air dried to afford 3-benzyl-5-bromo-2-ethyl-7-methylimidazo[4,5-b]pyridine.

1. filtrationthe solid residue was filtered
2. washwashed with water and air
3. customdried