反应详情

温度

80 °C

A mixture of 5.0 g of 4-(trifluoromethoxy)phenol, 5.87 g of 8-bromo-1-octanol, and 7.76 g of K2CO3 in 56 ml of anhydrous dimethylformamide is stirred and heated at 80° C. for 16 hours. The reaction mixture is poured into dilute HCl solution and the mixture is extracted three times with ethyl acetate. The combined extracts are washed with brine and dried over MgSO4. After filtration and concentration, the crude product is purified by flash chromatography on silica gel, eluting with a 4:1 hexane/ethyl acetate mixture to give the title compound 8-(4-(trifluoromethoxy)-phenoxy)-1-octanol.

1. extractionthe mixture is extracted three times with ethyl acetate
2. washThe combined extracts are washed with brine
3. dry with materialdried over MgSO4
4. filtrationAfter filtration and concentration
5. customthe crude product is purified by flash chromatography on silica gel
6. washeluting with a 4:1 hexane/ethyl acetate mixture