反应详情

A 12.7 g (76.7 mmole) sample of ethyl valerimidate hydrochloride [prepared from valeronitrile, ethanol, and hydrogen chloride gas as described by A. J. Hill and I. Rabinowitz, J. Am. Chem. Soc., 48, 734 (1926)] was dissolved in 33% (w/w) potassium carbonate solution (made by dissolving 15 g of K2CO3 in 30 ml of H2O) and immediately extracted with ether (3×40 ml). The combined ether layers were dried over Na2SO4, filtered, and concentrated in vacuo to give 7.09 g (72%) of the product as a clear oil, which was used directly in the next step.

1. extractionimmediately extracted with ether (3×40 ml)
2. dry with materialThe combined ether layers were dried over Na2SO4
3. filtrationfiltered
4. concentrationconcentrated in vacuo