反应详情

温度

24 °C

3-[(4-Amino-5-chloro-2-methoxyphenyl)methyl]-5-[4-(trifluoromethyl) phenyl]-1,3,4-oxadiazol-2(3H)-one (1.14 g, 2.9 mmol) and triethylamine (1.0 ml, 6.8 mmol) were taken up in anhydrous THF (20 ml) and transferred dropwise by cannula into a 20% solution of phosgene in toluene at 0° C. under N2. The reaction was stirred 2.5 h at 24° C., diluted with diethylether (1 vol), and filtered through a celite plug. Concentrated by rotary evaporation to gave a solid which was dissolved in dichloromethane (50 ml) under N2 and aminoacetaldehyde (0.42 ml, 2.9 mmol) was added. The solution was stirred 3 h and concentrated to remove solvent. The residue was taken up in 25 ml of formic acid (88%) and stirred 18 h at 24° C. The formic acid was removed by rotary evaporation the residue taken up in ethyl acetate, washed with saturated NaHCO3 solution and brine, and dried. Concentration on SiO2, and elution with 45% THF/benzene gave 850 mg (65%). mp 201°-202° C.; IR(KBr, ν=cm-1) 3414, 1792, 1694, 1330, 1236, 1136; 1H NMR (300 MHz, CDCl3) δ3.86 (3H, s), 4.97 (2H, s), 6.38 (2H, br, s), 6.99 (1H, s), 7.40 (1H, s), 7.71 (2H, d, J=8.4 Hz), 7.94 (2H, d, J=8.2 Hz), 10.28 (1H, br, s); MS(ESI)m/z: 465 (M--H-)

1. filtrationfiltered through a celite plug
2. concentrationConcentrated by rotary evaporation
3. customto gave a solid which
4. stirringThe solution was stirred 3 h
5. concentrationconcentrated
6. customto remove solvent
7. stirringstirred 18 h at 24° C
8. customThe formic acid was removed by rotary evaporation the residue
9. washwashed with saturated NaHCO3 solution and brine
10. customdried
11. concentrationConcentration
12. washon SiO2, and elution with 45% THF/benzene
13. customgave 850 mg (65%)