HRID362556

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID2383

Ethanamine, 2-methoxy-N-(2-methoxyethyl)-

C6H15NO2

HCID6228

N,N-Dimethylformamide

C3H7NO

HCID24386

Thionyl chloride

Cl2OS

结构：O=C(O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3ccsc3c12

HCID19353629

未命名化合物

PRODUCTS

生成物

结构：COCCN(CCOC)C(=O)c1cc(-c2ccc(OCc3ccccc3)cc2)c(=O)n2ccc3ccsc3c12

HCID56637135

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID1140

Toluene

C7H8

溶剂HCID8471

Triethylamine

C6H15N

溶剂HCID31275

1,4-Dioxane

C4H8O2

PROCEDURE

实验过程

From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with SOCl2 and DMF in toluene. Subsequent treatment with triethylamine and bis(2-methoxyethyl)-amine in dioxan.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-eddda7ffdb5b42428bdacc009c0bc003
来源数据集: uspto-grants-1999_02
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05869500
来源说明: uspto-grants-1999_02

反应 SMILES

[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16](=[O:31])[N:17]3[C:22](=[C:23]([C:25]([OH:27])=O)[CH:24]=2)[C:21]2[S:28][CH:29]=[CH:30][C:20]=2[CH:19]=[CH:18]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.O=S(Cl)Cl.CN(C=O)C.[CH3:41][O:42][CH2:43][CH2:44][NH:45][CH2:46][CH2:47][O:48][CH3:49]>C1(C)C=CC=CC=1.O1CCOCC1.C(N(CC)CC)C>[CH3:41][O:42][CH2:43][CH2:44][N:45]([CH2:46][CH2:47][O:48][CH3:49])[C:25]([C:23]1[CH:24]=[C:15]([C:12]2[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]3[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=3)=[CH:10][CH:11]=2)[C:16](=[O:31])[N:17]2[C:22]=1[C:21]1[S:28][CH:29]=[CH:30][C:20]=1[CH:19]=[CH:18]2)=[O:27]