Triethylamine → HCID 19353659, compound

HRID 362561Notes

Reaction equation

HRID 362561 reaction equation
[CH3:1][O:2][CH2:3][C:4](Cl)=O.Cl.[CH3:8][C:9]1[CH:13]=[C:12]([NH2:14])[S:11][N:10]=1.C(N(CC)CC)C>ClCCl.O1CCCC1>[CH3:1][O:2][CH2:3][CH2:4][NH:14][C:12]1[S:11][N:10]=[C:9]([CH3:8])[CH:13]=1

Participants

6

Reactant 3

HCID 8471TriethylamineHCID 96623Methoxyacetyl chlorideHCID 27239183-Methylisothiazol-5-ylamine hydrochloride

Product 1

HCID 19353659HCID 19353659, compound

Reagents, catalysts & solvents 2

HCID 6344DichloromethaneSolventHCID 8028TetrahydrofuranSolvent

Procedure

From methoxyacetyl chloride and 3-methyl-isothiazol-5-ylamine hydrochloride with triethylamine in dichloromethane. Then treatment with a borane-dimethyl sulphide complex in tetrahydrofuran.

Sources & evidence

ORD record
ord-f68fe66a57224eed8d128dfd1bd906b5
Source dataset
uspto-grants-1999_02
Patent number
US05869500

Reaction notes

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