反应详情

温度

70 °C

67.6 g (0.43 mol) 5-Hydroxy-3-methoxycarbonyl-1-methylpyrazole and 299.2 g (2.17 mol) potassium carbonate was dissolved in 1500 ml dimethylformamide and heated to 70° C. At this temperature chlorodifluoromethane was introduced over 2 hours and the mixture stirred at 80° C. for 1.5 hours. The reaction mixture was added to water and extracted 6 times with ethyl acetate. The combined organic phases were washed with saturated aqueous sodium chloride and dried over magnesium sulfate. The reaction solution was concentrated.

1. extractionextracted 6 times with ethyl acetate
2. washThe combined organic phases were washed with saturated aqueous sodium chloride
3. dry with materialdried over magnesium sulfate
4. concentrationThe reaction solution was concentrated