反应详情

1.5M Tetra(n-butyl)ammonium hydroxide (4.22 ml., 6.335 mole) was added to a suspension of thymine (0.913 g., 7.24 mole) in dimethylformamide (15 ml. ). The mixture was stirred for 10 minutes, and the dimethylformamide was removed in vacuo. Additional dimethylformamide (20 ml. ) was added to the white residue, and removed in vacuo. This process was repeated four times and the residue was dried under a vacuum (0.1 mm) at 50° C. overnight affording the tetra(n-butyl)ammonium salt of thymine.

1. customthe dimethylformamide was removed in vacuo
2. additionAdditional dimethylformamide (20 ml. ) was added to the white residue
3. customremoved in vacuo
4. customthe residue was dried under a vacuum (0.1 mm) at 50° C. overnight