Hydrochloric Acid → HCID 10398910, compound

HRID 364001Notes

Reaction equation

HRID 364001 reaction equation
[C:1]([O:5][CH3:6])(=[O:4])[CH:2]=[CH2:3].[CH3:7][O:8][C:9]1[CH:15]=[CH:14][C:12](N)=[CH:11][CH:10]=1.[ClH:16]>C(#N)C>[Cl:16][CH:2]([CH2:3][C:12]1[CH:14]=[CH:15][C:9]([O:8][CH3:7])=[CH:10][CH:11]=1)[C:1]([O:5][CH3:6])=[O:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7294Methyl AcrylateHCID 7732P-Anisidine

Product 1

HCID 10398910HCID 10398910, compoundYield 57.3%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure of Example I, 339 mmols of methyl acrylate were reacted with 25 mmols of crude 4-methoxyaniline in 30 mL of acetonitrile and in the presence of 38 mmols of concentrated HCl and 2.5 mmols of cuprous oxide. The process resulted in a 57.3% yield of methyl 2-chloro-3-(4-methoxyphenyl)propionate.

Sources & evidence

ORD record
ord-e3aefe0f07134f7eb17a0fd4334d94d2
Source dataset
uspto-grants-1986_08
Patent number
US04604243

Reaction notes

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