Hydrochloric Acid → HCID 20239948, compound

HRID 364002Notes

Reaction equation

HRID 364002 reaction equation
[C:1]([O:6][CH3:7])(=[O:5])[C:2]([CH3:4])=[CH2:3].[CH3:8][O:9][C:10]1[CH:11]=[C:12]([CH:14]=[CH:15][C:16]=1[O:17][CH3:18])N.[ClH:19]>C(#N)C>[Cl:19][C:2]([CH3:4])([CH2:3][C:14]1[CH:12]=[CH:11][C:10]([O:9][CH3:8])=[C:16]([O:17][CH3:18])[CH:15]=1)[C:1]([O:6][CH3:7])=[O:5]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6658Methyl MethacrylateHCID 227703,4-Dimethoxyaniline

Product 1

HCID 20239948HCID 20239948, compoundYield 39.2%

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

Following the general procedure of Example I, 280 mmols of distilled methyl methacrylate were reacted with 25 mmols of 3,4-dimethoxyaniline in 30 mL of acetonitrile and in the presence of 42 mmols of concentrated HCl and 2.5 mmols of cuprous oxide. The process resulted in a 39.2% yield of methyl 2-chloro-2-methyl-3-(3,4-dimethoxyphenyl)propionate.

Sources & evidence

ORD record
ord-efa4177446c44d5b9c59dcbc4ffd0314
Source dataset
uspto-grants-1986_08
Patent number
US04604243

Reaction notes

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