HCID 19938212, compound → HCID 19938195, compound

HRID 36447Notes

Reaction equation

HRID 36447 reaction equation
COC[O:4][C:5]1[CH:10]=[CH:9][C:8]([CH:11]([C:28]2[CH:33]=[CH:32][C:31]([O:34]COC)=[CH:30][CH:29]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:18]([CH3:27])[C:19]([CH:21]2[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]2)=[O:20])=[CH:7][CH:6]=1>C(OCC)(=O)C.Cl>[OH:34][C:31]1[CH:30]=[CH:29][C:28]([CH:11]([C:8]2[CH:7]=[CH:6][C:5]([OH:4])=[CH:10][CH:9]=2)[C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][C:13]=2[N:18]([CH3:27])[C:19]([CH:21]2[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]2)=[O:20])=[CH:33][CH:32]=1

Participants

4

Reactant 1

HCID 19938212HCID 19938212, compound

Product 1

HCID 19938195HCID 19938195, compoundYield 17.2%

Reagents, catalysts & solvents 2

HCID 313Hydrochloric AcidSolventHCID 8857Ethyl AcetateSolvent

Procedure

In 50 ml of ethyl acetate saturated with hydrogen chloride was dissolved 2.18 g of Compound 137 obtained by Example 137, and the solution was stirred for 1 hour. Thereafter, the solvent was evaporated under reduced pressure, and the residue was recrystallized from methanol to afford 0.31 g of the desired compound (Compound 138).

Workup

  1. customThereafter, the solvent was evaporated under reduced pressure
  2. customthe residue was recrystallized from methanol

Sources & evidence

ORD record
ord-6cc0d8f109b1402ab5ccb3f8e17ba093
Source dataset
uspto-grants-1995_05
Patent number
US05413997

Reaction notes

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