Dimethylformamide → HCID 13689354, compound

HRID 365133Notes

Reaction equation

HRID 365133 reaction equation
[H-].[Na+].F[C:4]1[CH:24]=[CH:23][CH:22]=[CH:21][C:5]=1[CH2:6][N:7]1[CH:11]=[CH:10][CH:9]=[C:8]1[CH:12]([CH:14]1[CH2:19][CH2:18][N:17]([CH3:20])[CH2:16][CH2:15]1)[OH:13].CN(C)C=O>C1C=CC=CC=1>[CH3:20][N:17]1[CH2:18][CH2:19][CH:14]([CH:12]2[C:8]3=[CH:9][CH:10]=[CH:11][N:7]3[CH2:6][C:5]3[CH:21]=[CH:22][CH:23]=[CH:24][C:4]=3[O:13]2)[CH2:15][CH2:16]1

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 24758Sodium hydrideHCID 13689353HCID 13689353, compound

Product 1

HCID 13689354HCID 13689354, compound

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent2×

Procedure

To a suspension of sodium hydride (2.0 g, 50% in oil, treated with hexanes, 0.04 mole) in 50 ml benzene was added a suspension of [1-(2-fluorobenzyl)-2-pyrryl]-[(1-methyl)piperidin-4-yl]methanol (10.0 g, 0.033 mole) in 100 ml benzene, followed by 50 ml dimethylformamide.

Workup

  1. additionwas added

Sources & evidence

ORD record
ord-3df129a011d24c29826f71199ada4395
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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