Potassium Carbonate → HCID 20191667, compound

HRID 365136Notes

Reaction equation

HRID 365136 reaction equation
[O:1]1[C:7]2[CH:8]=[CH:9][CH:10]=[CH:11][C:6]=2[CH:5]=[N:4][CH:3]=[CH:2]1.Cl[CH2:13][CH2:14][CH2:15][C:16]1[C:20]2[CH:21]=[CH:22][C:23]([F:25])=[CH:24][C:19]=2[O:18][N:17]=1.[C:26]([O-:29])([O-:28])=O.[K+].[K+]>CN(C=O)C>[C:7]([OH:1])(=[O:18])[C:26]([OH:29])=[O:28].[F:25][C:23]1[CH:22]=[CH:21][C:20]2[C:16]([CH2:15][CH2:14][CH2:13][N:4]3[CH2:5][CH2:7][CH:8]([CH:9]4[C:10]5=[CH:11][CH:6]=[CH:5][N:4]5[CH2:3][C:2]5[CH:11]=[CH:6][CH:7]=[CH:8][C:26]=5[O:29]4)[CH2:2][CH2:3]3)=[N:17][O:18][C:19]=2[CH:24]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 109108803-(3-Chloropropyl)-6-fluorobenzo[d]isoxazoleHCID 14712340HCID 14712340, compound

Product 1

HCID 20191667HCID 20191667, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

To 50 ml dry DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo2,1-c][1,4]benzoxazepine (3.0 g, 0.0112 mole), 3-(3-chloropropyl)-6-fluoro-1,2-benzisoxazole (4.2 g, 0.02 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

Sources & evidence

ORD record
ord-0c183e3d50aa4ffe893db4480b73dc45
Source dataset
uspto-grants-1986_08
Patent number
US04608374

Reaction notes

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