Dimethylformamide → HCID 20191665, compound

HRID 365141Notes

Reaction equation

[NH:1]1[CH2:6][CH2:5][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:3][CH2:2]1.[CH:21](Br)([CH3:23])[CH3:22].[C:25]([O-:28])([O-:27])=O.[K+].[K+].CN(C=[O:35])C>>[C:9]([OH:8])(=[O:35])[C:25]([OH:28])=[O:27].[CH3:22][CH:21]([N:1]1[CH2:2][CH2:3][CH:4]([CH:7]2[C:13]3=[CH:14][CH:15]=[CH:16][N:12]3[CH2:11][C:10]3[CH:17]=[CH:18][CH:19]=[CH:20][C:9]=3[O:8]2)[CH2:5][CH2:6]1)[CH3:23]

Participants

Reactant 4

HCID 6228Dimethylformamide

HCID 63582-Bromopropane

HCID 11430Potassium Carbonate

HCID 1368935811-(piperdin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine

Product 1

HCID 20191665HCID 20191665, compound

Procedure

To 509 ml DMF were added 11-(piperidin-4-yl)-5H,11H-pyrrolo[2,1-c][1,4]benzoxazepine (6.4 g, 0.024 mole), isopropyl bromide (2.8 ml, 0.03 mole), milled K2CO3 (10 g, 0.07 mole) and KI (0.01 g).

Sources & evidence

ORD record: ord-884f08399dad4e07b68394fc5424adeb
Source dataset: uspto-grants-1986_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04608374

Reaction notes

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