反应详情

A solution of 9-chlorofluorene (8.4 g), triethylamine (0.85 mL) and piperazine (27 g) in THF (200 mL) was refluxed under argon for 6 hours. It was then filtered and the solvent was removed under vacuum. The crude product was washed with water, chromatographed on silica gel and eluted with 5% MeOH saturated with NH3 in CH2Cl2 to afford the title compound (8.5 g).

1. filtrationIt was then filtered
2. customthe solvent was removed under vacuum
3. washThe crude product was washed with water
4. customchromatographed on silica gel
5. washeluted with 5% MeOH saturated with NH3 in CH2Cl2