Hydrochloric Acid → HCID 22326956, compound

HRID 366232Notes

Reaction equation

HRID 366232 reaction equation
C(O[C:6](=O)[N:7](C)[CH:8]([C:20]1[O:24][N:23]=[C:22]([CH3:25])[N:21]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=1)(C)(C)C.[ClH:28]>C(OCC)(=O)C>[ClH:28].[CH3:6][NH:7][CH:8]([C:20]1[O:24][N:23]=[C:22]([CH3:25])[N:21]=1)[CH2:9][C:10]1[CH:19]=[CH:18][C:17]2[C:12](=[CH:13][CH:14]=[CH:15][CH:16]=2)[CH:11]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 22949427HCID 22949427, compound

Product 1

HCID 22326956HCID 22326956, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

N-Methyl-N-[1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(2-naphtyl)ethyl]carbamic acid tertbutyl ester (3.3 g, 9.0 mmol) was dissolved in a saturated solution of hydrogen chloride in ethyl acetate (75 mL). After 3 hours at 20° C. the reaction mixture was filtered to give 1.52 g of (R) N-methyl-N-{1-(3-methyl-1,2,4-oxadiazol-5-yl)-2-(2-naphthyl)ethyl}amine hydrochloride.

Workup

  1. filtrationAfter 3 hours at 20° C. the reaction mixture was filtered

Sources & evidence

ORD record
ord-94a70827d790497fa12eabce315ee5aa
Source dataset
uspto-grants-2000_10
Patent number
US06127391

Reaction notes

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