反应详情

4-Benzhydrylpiperidine (10 mmol, 2.87 g) is slurried in n-butanol (30 mL), and K2CO3 (s) (2.76 g, 10 mmol) or diisopropylethylamine (20 mmol, 2.5 g) and 3-bromopropanol (10 mmol, 1.39 g) are added to the slurry. The stirred mixture is refluxed for about 7 hours under N2 (g), filtered, and concentrated in vacuo. The residue is dissolved in hot CHCl3, filtered and concentrated in vacuo to yield crude product as an oil (3.0-3.1 g) which is used without further purification.

1. temperatureThe stirred mixture is refluxed for about 7 hours under N2 (g)
2. filtrationfiltered
3. concentrationconcentrated in vacuo
4. dissolutionThe residue is dissolved in hot CHCl3
5. filtrationfiltered
6. concentrationconcentrated in vacuo