反应详情

Methyl 2-(5-acetyl-2-hydroxyphenyl)acetate (8.0 g) was dissolved in 120 ml of N,N-dimethylformamide, 5 ml of benzyl bromide and 5.8 g of potassium carbonate were added to the solution, and the mixture was stirred at room temperature for 16 hours. About 100 g of ice and 200 ml of hexane were added to the reaction solution, and the mixture was vigorously stirred while adding 200 ml of water. Thereafter, the precipitated crystals were collected by filtration and recrystallized from methylene chloride-hexane to give 10.1 g of methyl 2-(5-acetyl-2-benzyloxyphenyl)acetate having a melting point of 85 to 87° C.

1. stirringthe mixture was vigorously stirred
2. filtrationThereafter, the precipitated crystals were collected by filtration
3. customrecrystallized from methylene chloride-hexane