5-Chloroindole → HCID 9903606, compound

HRID 367359Notes

Reaction equation

HRID 367359 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[CH:5]2.[CH2:11]1[CH:19]2[N:14]([CH2:15][CH2:16][C:17](=O)[CH2:18]2)[CH2:13][CH2:12]1>CC(=O)OCC>[CH2:11]1[CH:19]2[N:14]([CH2:15][CH:16]=[C:17]([C:5]3[C:4]4[C:8](=[CH:9][CH:10]=[C:2]([Cl:1])[CH:3]=4)[NH:7][CH:6]=3)[CH2:18]2)[CH2:13][CH2:12]1

Participants

4

Reactant 2

HCID 871105-ChloroindoleHCID 11240524Octahydroindolizin-7-one

Product 1

HCID 9903606HCID 9903606, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

5-Chloro-1H-indole (1.00 g, 6.63 mmol) and 7-octahydroindolizinone (1.39 g, 9.95 mmol) were converted to product by the procedure of Preparation 4 to give 595 mg. (33.1%). EA calculated for C16H17N2Cl: C, 70.45; H, 6.28; N, 10.27. Found: C, 70.60; H, 6.46; N, 10.28.

Workup

  1. customto give 595 mg

Sources & evidence

ORD record
ord-c7ef9a3c32c54135896fe101ca7664b2
Source dataset
uspto-grants-2000_10
Patent number
US06133290

Reaction notes

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