反应详情

A mixture of 6.56 g of 1,12-dibromododecane, 3.24 g of N-phenylpiperazine, 2.53 g of triethylamine, and 50 ml of toluene was heated under reflux for 2 hours. To the reaction mixture was added 100 ml of ethyl acetate, and the mixture was washed successively with water and a saturated sodium chloride aqueous solution, and dried over magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was subjected to column chromatography using a 1:2 mixture of ethyl acetate and hexane as a developing solvent to yield 4.1 g of 1-bromo-12-(4-phenylpiperazinyl)dodecane (m.p.=26.0°-28.0° C.).

1. temperaturewas heated
2. temperatureunder reflux for 2 hours
3. washthe mixture was washed successively with water
4. dry with materiala saturated sodium chloride aqueous solution, and dried over magnesium sulfate
5. customThe solvent was evaporated under reduced pressure
6. additiona 1:2 mixture of ethyl acetate and hexane as a developing solvent