反应详情

In 100 ml of acetone, 8.0 g of 4-bromophenol, 8.9 g of n-octylbromide, and 13 g of potassium carbonate were heated to reflux for 12 hours. After the solvent was distilled off under a reduced pressure, the residue thus obtained was extracted with isopropyl ether, washed with a 5% aqueous sodium hydroxide solution and water in turn. The ether was distilled off, and the residue was purified by a silica gel column chromatography using a mixed solvents of n-hexane and diethyl ether (10:1) and subjected to distillation to obtain 8.4 g of 4-bromo-1-n-octyloxybenzene.

1. temperatureto reflux for 12 hours
2. distillationAfter the solvent was distilled off under a reduced pressure
3. customthe residue thus obtained
4. extractionwas extracted with isopropyl ether
5. washwashed with a 5% aqueous sodium hydroxide solution and water in turn
6. distillationThe ether was distilled off
7. customthe residue was purified by a silica gel column chromatography
8. distillationsubjected to distillation