Isopropyl isocyanate → HCID 23288444, compound

HRID 368388Notes

Reaction equation

HRID 368388 reaction equation
[CH:1]([N:4]=[C:5]=[O:6])([CH3:3])[CH3:2].[C:7]1([S:13]([NH:16][C:17]2[CH:23]=[C:22]([C:24]#[N:25])[CH:21]=[CH:20][C:18]=2[NH2:19])(=[O:15])=[O:14])[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=1>CN(C=O)C>[C:7]1([S:13]([NH:16][C:17]2[CH:23]=[C:22]([C:24]#[N:25])[CH:21]=[CH:20][C:18]=2[NH:19][C:5]([NH:4][CH:1]([CH3:3])[CH3:2])=[O:6])(=[O:15])=[O:14])[CH:8]=[CH:9][CH:10]=[CH:11][CH:12]=1

Participants

4

Reactant 2

HCID 61277Isopropyl isocyanateHCID 21714407HCID 21714407, compound

Product 1

HCID 23288444HCID 23288444, compoundYield 65%

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
80 °C

Procedure

To a solution of isopropylisocyanate (31.2 mg, 0.37 mmol) in DMF (0.5 ml), 2-benzenesulfonylamino-4-cyanoaniline (100 mg, 0.37 mmol) was added. The reaction mixture was stirred at 80° C. for 3 hours. Chromatography of the resulting liquid on silica gel gave the desired product (85 mg, 65%). EI-MS m/z 359.4 (M+).

Sources & evidence

ORD record
ord-dcde1a12cae741909766b5d610c83bec
Source dataset
uspto-grants-2000_10
Patent number
US06133319

Reaction notes

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