反应详情

温度

90 °C

2-Chloromethylquinoline hydrochloride (6.42 g, 30 mmol), 4-hydroxybenzaldehyde (3.66 g, 30 mmol) and potassium carbonate (9.12 g, 66 mmol) were combined, to which 50 ml of DMF were added. The resulting mixture was stirred overnight at 90° C. The solvent was driven off under reduced pressure, the residue was extracted with ethyl acetate. The organic layer was washed with 1 N aqueous solution of sodium hydroxide and a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, and then concentrated under reduced pressure, whereby 7.19 g of the title compound were obtained (yield: 91%).

1. additionwere added
2. extractionthe residue was extracted with ethyl acetate
3. washThe organic layer was washed with 1 N aqueous solution of sodium hydroxide
4. dry with materiala saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate
5. concentrationconcentrated under reduced pressure