反应详情

The ester 35a (405 mg, 1.0 mmol) was dissolved in 15 ml THF and 50 ml methanol was added. Water (approximately 10 ml) was added until the solution remained cloudy with vigorous stirring, at which time lithium hydroxide monohydrate (840 mg, 20.0 mmol) was added. The reaction mixture was refluxed overnight, acidified with concentrated HCl and cooled. The precipitate was filtered, washed with water and air dried to yield 279 mg (71%) of a white powder.

1. additionwas added
2. temperatureThe reaction mixture was refluxed overnight
3. temperaturecooled
4. filtrationThe precipitate was filtered
5. washwashed with water and air
6. customdried