Phenethylamine → N-(2-Phenylethyl)propanamide

HRID 369992Notes

Reaction equation

HRID 369992 reaction equation
[CH2:1]([NH2:9])[CH2:2][C:3]1[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1.[C:10](Cl)(=[O:13])[CH2:11][CH3:12].C(N(CC)CC)C>C(Cl)Cl>[C:3]1([CH2:2][CH2:1][NH:9][C:10](=[O:13])[CH2:11][CH3:12])[CH:8]=[CH:7][CH:6]=[CH:5][CH:4]=1

Participants

5

Reactant 3

HCID 1001PhenethylamineHCID 8471TriethylamineHCID 62324Propionyl chloride

Product 1

HCID 94894N-(2-Phenylethyl)propanamide

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The title compound was prepared in a reaction between phenethylamine (12.1 g, 100 mmol), propionyl chloride (9.25 g, 100 mmol) and triethylamine (20 ml) in methylene chloride (200 ml). The product (10.1 g) was used without purification; MS [M+H]+ 178.

Workup

  1. customThe product (10.1 g) was used without purification

Sources & evidence

ORD record
ord-b43314afbe2b4d14917fc8f07abfcb33
Source dataset
uspto-grants-2000_10
Patent number
US06140322

Reaction notes

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