反应详情

温度

-10 °C

0.28 g of triethylamine and 0.96 ml of trifluoroacetic acid were added to 0.28 g of 4, and the mixture was cooled to -10° C. 0.25 ml of trifluoroacetic anhydride was added drop-by-drop. The resulting mixture was allowed to warm to room temperature and stirred for 90 minutes. Volatile materials were evaporated under reduced pressure, and the residue, an oil, was eluted through a column of florisil, using ethyl acetate as eluent. After evaporation of the solvent, the resulting oil was stripped under reduced pressure to give 8, as a brown solid.

1. temperatureto warm to room temperature
2. customVolatile materials were evaporated under reduced pressure
3. washthe residue, an oil, was eluted through a column of florisil
4. customAfter evaporation of the solvent
5. customto give 8