Sodium hydride → HCID 12795064, compound

HRID 371739Notes

Reaction equation

HRID 371739 reaction equation
O[CH2:2][CH2:3][N:4]1[CH:8]=[C:7]([CH3:9])[C:6]([C:10]([O:12][CH3:13])=[O:11])=[C:5]1[CH2:14][C:15]([O:17][CH3:18])=[O:16].S(OCCN1C=C(C)C(C(OC)=O)=C1CC(OC)=O)(C)(=O)=O.[H-].[Na+]>CN(C)C=O>[CH3:9][C:7]1[C:6]([C:10]([O:12][CH3:13])=[O:11])=[C:5]2[CH:14]([C:15]([O:17][CH3:18])=[O:16])[CH2:2][CH2:3][N:4]2[CH:8]=1

Participants

5

Reactant 3

HCID 24758Sodium hydrideHCID 12794997HCID 12794997, compoundHCID 12795004HCID 12795004, compound

Product 1

HCID 12795064HCID 12795064, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

By following the method of Example 2, methyl N-(2-hydroxyethyl)-3-carbomethoxy-4-methylpyrrole-2-acetate (IV, R = CH3) is converted into methyl N-(2-mesyloxyethyl)-3-carbomethoxy-4-methylpyrrole-2-acetate and then cyclized with sodium hydride in dimethylformamide, in accordance with the method of Example 8, to afford dimethyl 1,2-dihydro-6-methyl-3H-pyrrolo[1,2-a]pyrrole-1,7-dicarboxylate.

Sources & evidence

ORD record
ord-ecf5a3807c824f1f980b4d42d95bb793
Source dataset
uspto-grants-1978_05
Patent number
US04087539

Reaction notes

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