Hydrochloric Acid → 4-[(2-Methylimidazo(1,2-a)pyridin 3-yl)methyl]benzonitrile hydrochloride

HRID 37214Notes

Reaction equation

HRID 37214 reaction equation
[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11][C:12]1[CH:19]=[CH:18][C:15]([C:16]#[N:17])=[CH:14][CH:13]=1.C(OCC)(=O)C.[ClH:26]>C(O)C>[ClH:26].[CH3:1][C:2]1[N:3]=[C:4]2[CH:9]=[CH:8][CH:7]=[CH:6][N:5]2[C:10]=1[CH2:11][C:12]1[CH:13]=[CH:14][C:15]([C:16]#[N:17])=[CH:18][CH:19]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 8857Ethyl AcetateHCID 190324654-[(2-Methylimidazo(1,2-a)pyridin3-yl)methyl]benzonitrile

Product 1

HCID 190324644-[(2-Methylimidazo(1,2-a)pyridin 3-yl)methyl]benzonitrile hydrochloride

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

A mixture of 5 g of the product of Stage C, 80 ml of ethyl acetate and 3.5 ml of 6.6N hydrochloric acid in ethanol was ice-cooled, separated, washed with ethyl acetate and dried under reduced pressure at 80° C. to obtain 5 g of the expected product melting at 230° C.

Workup

  1. temperaturecooled
  2. customseparated
  3. washwashed with ethyl acetate
  4. customdried under reduced pressure at 80° C.

Sources & evidence

ORD record
ord-b3cf45a581c645b7b3b59ebc105efcb5
Source dataset
uspto-grants-1995_05
Patent number
US05420138

Reaction notes

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