反应详情

17.5 g isatoic anhydride and 2.66 g 4-dimethylaminopyridine are combined in 500 ml tetrahydrofuran. 9.32 g of pyrrolidine is added and the mixture is heated at reflux overnight. The mixture is concentrated in vacuo, the residue taken into ethyl acetate and the organic solution washed with citric acid solution, water and brine and dried over magnesium sulfate. The solution is filtered, evaporated and the residue triturated in ether/hexane (1:5) to give N-(2-aminobenzoyl)pyrrolidine, m.p. 79°-81° C.

1. temperaturethe mixture is heated
2. temperatureat reflux overnight
3. concentrationThe mixture is concentrated in vacuo
4. washthe organic solution washed with citric acid solution, water and brine
5. dry with materialdried over magnesium sulfate
6. filtrationThe solution is filtered
7. customevaporated
8. customthe residue triturated in ether/hexane (1:5)