Hydrochloric Acid → HCID 3596801, compound

HRID 374382Notes

Reaction equation

HRID 374382 reaction equation
[CH:1]1([NH2:8])[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1.C([N:11]([CH2:14][CH3:15])CC)C.[C:16](Cl)(=[O:26])[C:17]1[CH:25]=[CH:24][CH:23]=[C:19]([C:20](Cl)=[O:21])[CH:18]=1.Cl>C(Cl)Cl.O>[CH:1]1([NH:8][C:16](=[O:26])[C:17]2[CH:25]=[CH:24][CH:23]=[C:19]([C:20]([NH:11][CH:14]3[CH2:15][CH2:6][CH2:7][CH2:1][CH2:2][CH2:3]3)=[O:21])[CH:18]=2)[CH2:7][CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

7

Reactant 4

HCID 313Hydrochloric AcidHCID 2899CycloheptylamineHCID 7451Isophthaloyl chlorideHCID 8471Triethylamine

Product 1

HCID 3596801HCID 3596801, compoundYield 96.1%

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6344DichloromethaneSolvent

Procedure

20.8 g of cycloheptylamine and 20.25 g of triethylamine were dissolved in 500 ml of methylenechloride, and then, 17.0 g of iso-phthaloyl chloride was added to thereto. The mixture was stiired at room temperature for 2 hours, and 500 ml of water was added to the reaction mixture. Then, conc. HCl was added thereto while stirring. Precipitated soli material was collected by filtration, washed with methylene chloride and water successively, and dried giving 28.7 g of N,N'-dicycloheptylisophthalamide.

Workup

  1. filtrationPrecipitated soli material was collected by filtration
  2. washwashed with methylene chloride and water successively
  3. customdried

Sources & evidence

ORD record
ord-d824b3f0f26d4e5ab539f6da80afb924
Source dataset
uspto-grants-1992_11
Patent number
US05166429

Reaction notes

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