反应详情

6-Chloronicotinic acid (8.0g) was added to 85% hydrazine hydrate (35 ml). The reaction mixture was placed in a 100° C. oil bath for 4 hours. The homogeneous reaction mixture was concentrated to dryness to give a white solid. The solid was dissolved in water and on acidification to pH 5.5 with concentrated hydrochloric acid a precipitate formed. The precipitate was isolated by filtration and the solid was washed with 95% ethanol and ether to give 6.0 g of a pale brown solid; yield 77% m.p. 292°-293° C.;

1. customwas placed in a 100° C.
2. customfor 4 hours
3. concentrationThe homogeneous reaction mixture was concentrated to dryness
4. customto give a white solid
5. customformed
6. customThe precipitate was isolated by filtration
7. washthe solid was washed with 95% ethanol and ether