反应详情

温度

-78 °C

4-Bromophenol(57.8 mmoles, 10.0 g) was added to a -30° C. solution of isobutylene (40 ml) and methylene chloride (50 ml) and then cooled to -78° C. Trifluoromethanesulfonic acid (4 mmoles, 0.35 ml) was added. The mixture was held at -78° C. for 4 hours and then allowed to warm to room temperature. Triethylamine (0.5 ml) was added; the solvent was removed. The residue was chromatographed over silica gel eluted with 1% ethyl acetate in hexane to yield 12.4 g. (MS)

1. temperatureto warm to room temperature
2. customthe solvent was removed
3. customThe residue was chromatographed over silica gel
4. washeluted with 1% ethyl acetate in hexane
5. customto yield 12.4 g