Dicyclohexylcarbodiimide → 1-[1-oxo-2-(4-Nitro-1H-imidazol-1-yl)octyl]-L-proline benzyl ester

HRID 375119Notes

Reaction equation

HRID 375119 reaction equation
C(N(C(C)C)CC)(C)C.Cl.[CH2:11]([O:18][C:19](=[O:25])[C@@H:20]1[CH2:24][CH2:23][CH2:22][NH:21]1)[C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1.[N+:26]([C:29]1[N:30]=[CH:31][N:32]([CH:34]([CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[C:35](O)=[O:36])[CH:33]=1)([O-:28])=[O:27].OC1C2N=NNC=2C=CC=1.C1(N=C=NC2CCCCC2)CCCCC1>CN(C=O)C.C(OCC)(=O)C>[CH2:11]([O:18][C:19](=[O:25])[C@@H:20]1[CH2:24][CH2:23][CH2:22][N:21]1[C:35](=[O:36])[CH:34]([N:32]1[CH:33]=[C:29]([N+:26]([O-:28])=[O:27])[N:30]=[CH:31]1)[CH2:38][CH2:39][CH2:40][CH2:41][CH2:42][CH3:43])[C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=1

Participants

8

Reactant 5

HCID 10868DicyclohexylcarbodiimideHCID 81531DiisopropylethylamineHCID 2733413Proline benzyl ester hydrochlorideHCID 100836862-(4-nitro-1H-imidazol-1-yl)octanoic acidHCID 178418300HCID 178418300, compound

Product 1

HCID 537038381-[1-oxo-2-(4-Nitro-1H-imidazol-1-yl)octyl]-L-proline benzyl esterYield 30.4%

Reagents, catalysts & solvents 2

HCID 6228DimethylformamideSolvent2×HCID 8857Ethyl AcetateSolvent

Procedure

Diisopropylethylamine (39.6 mmoles, 5.1 g) was added to a solution of L-proline benzyl ester hydrochloride (39.6 mmoles, 10.1 g) in 20 ml DMF at 0° and stirred for 1 hour. The solution was added to 2-(4-nitro-1H-imidazol-1-yl) octanoic acid (39.6 mmoles, 10.1 g) and hydroxybenzotriazole (43 mmoles, 5.8 g) in 10 ml DMF, and stirred for 30 minutes. Dicyclohexylcarbodiimide (43 mmoles, 8.97 g) was added portionwise over 2 hours. Ethyl acetate (50 ml) was added. The solution was filtered, dried over sodium sulfate and concentrated. The oil was chromatographed over silica gel eluted with 40% ethyl acetate in hexane to yield 5.32 g of 1-[1-oxo-2-(4-Nitro-1H-imidazol-1-yl)octyl]-L-proline benzyl ester.

Workup

  1. stirringstirred for 30 minutes
  2. filtrationThe solution was filtered
  3. dry with materialdried over sodium sulfate
  4. concentrationconcentrated
  5. customThe oil was chromatographed over silica gel
  6. washeluted with 40% ethyl acetate in hexane

Sources & evidence

ORD record
ord-b576186395aa42009b4de5c1a96d6ae1
Source dataset
uspto-grants-1996_01
Patent number
US05484780

Reaction notes

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