Hydroxylamine → HCID 22009535, compound

HRID 376259Notes

Reaction equation

HRID 376259 reaction equation
[CH:1]1([C:6]2[O:7][C:8]3[C:9](=[C:11]([CH:17]=O)[CH:12]=[CH:13][C:14]=3[O:15][CH3:16])[CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[NH2:19]O.C([O-])=O.[Na+].C(OCC)(=O)C>C(O)=O>[CH:1]1([C:6]2[O:7][C:8]3[C:9](=[C:11]([C:17]#[N:19])[CH:12]=[CH:13][C:14]=3[O:15][CH3:16])[CH:10]=2)[CH2:5][CH2:4][CH2:3][CH2:2]1

Participants

6

Reactant 4

HCID 787HydroxylamineHCID 8857Ethyl AcetateHCID 2723810Sodium FormateHCID 22009525HCID 22009525, compound

Product 1

HCID 22009535HCID 22009535, compound

Reagents, catalysts & solvents 1

HCID 284Formic AcidSolvent

Procedure

27.6 g of 2-cyclopentyl-7-methoxybenzofuran-4-carbaldehyde are heated to reflux for 1.5 h with 11.6 g of hydroxylamine and 19.7 g of sodium formate in 250 ml of formic acid. The cooled solution is stirred in about 1.5 l of a 1:1 mixture of ice water and ethyl acetate, and the organic phase is separated off, dried over ignited potassium carbonate and evaporated in vacuo. The residual oil is sufficiently pure for further processing.

Workup

  1. customthe organic phase is separated off
  2. customdried
  3. customevaporated in vacuo

Sources & evidence

ORD record
ord-1177e708923641bcb8787ee5e335f871
Source dataset
uspto-grants-2000_02
Patent number
US06020340

Reaction notes

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