Triethylamine → methyl N-(BOC)-8-aminomethyl-5,6,7,8-tetrahydro-2-naphthoate

HRID 376803Notes

Reaction equation

HRID 376803 reaction equation
[NH2:1][CH2:2][CH:3]1[C:12]2[CH:11]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1.C(N(CC)CC)C.[C:24]([O:28][C:29](ON=C(C1C=CC=CC=1)C#N)=[O:30])([CH3:27])([CH3:26])[CH3:25].C(OCC)(=O)C>O1CCCC1>[C:29]([NH:1][CH2:2][CH:3]1[C:12]2[CH:11]=[C:10]([C:13]([O:15][CH3:16])=[O:14])[CH:9]=[CH:8][C:7]=2[CH2:6][CH2:5][CH2:4]1)([O:28][C:24]([CH3:27])([CH3:26])[CH3:25])=[O:30]

Participants

6

Reactant 4

HCID 8471TriethylamineHCID 8857Ethyl AcetateHCID 938652-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrileHCID 14756556Methyl 8-(aminomethyl)-5,6,7,8-tetrahydronaphthalene-2-carboxylate

Product 1

HCID 19359193methyl N-(BOC)-8-aminomethyl-5,6,7,8-tetrahydro-2-naphthoateYield 47.2%

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Part D--A solution of methyl 8-aminomethyl-5,6,7,8-tetrahydro-2-naphthoate (0.78 g, 0.0036 mol) and triethylamine (0.55 mL, 0.40 g, 0.004 mol) in aqueous tetrahydrofuran (50%, 75 mL) was added, portionwise as a solid, 2-(tert-butoxycarbonyloxyimino)-2-phenylacetonitrile (0.99 g, 0.004 mol). All was stirred at ambient temperature over 3 hours. The solution was concentrated to half volume and extracted with diethylether. The aqueous layer was then acidified to a pH of 1.0 using hydrochloric acid (1N) and then extraced with ethyl acetate. The combined organic layers were dried over anhydrous magnesium sulfate and evaporated to dryness under reduced pressure. The residue was purified by flash chromatography using hexane:ethyl acetate::8:2 to give methyl N-(BOC)-8-aminomethyl-5,6,7,8-tetrahydro-2-naphthoate (0.54 g, 0.0017 mol, 47%) as a white solid. mp=72-80° C.; 1H NMR (DMSO) d 13.8 (s, 1H), 7.8-7.65 (m, 3H), 7.6-7.5 (m, 3H), 7.25-7.20 (m, 1H), 7.15-7.05 (m, 1H), 3.9-3.8 (m, 1H), 3.2-2.8 (m, 4H), 1.8-1.6 (m, 3H), 1.4 (s, 6H).

Workup

  1. concentrationThe solution was concentrated to half volume
  2. extractionextracted with diethylether
  3. dry with materialThe combined organic layers were dried over anhydrous magnesium sulfate
  4. customevaporated to dryness under reduced pressure
  5. customThe residue was purified by flash chromatography

Sources & evidence

ORD record
ord-2ac28901b69d464fb5948f18e9995a25
Source dataset
uspto-grants-2000_02
Patent number
US06022523

Reaction notes

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