3-Amino-1,2-propanediol → HCID 19358861, compound

HRID 377521Notes

Reaction equation

HRID 377521 reaction equation
[CH2:1]([C:3]1[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[C:14]([CH3:19])[N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=[C:5](S(C)(=O)=O)[N:4]=1)[CH3:2].[NH2:24][CH2:25][CH:26]([OH:29])[CH2:27][OH:28]>CN1CCCC1=O>[OH:29][CH:26]([CH2:27][OH:28])[CH2:25][NH:24][C:5]1[N:4]=[C:3]([CH2:1][CH3:2])[C:12]2[NH:11][C:10](=[O:13])[C:9]3=[C:14]([CH3:19])[N:15]=[C:16]([CH2:17][CH3:18])[N:8]3[C:7]=2[N:6]=1

Participants

4

Reactant 2

HCID 735613-Amino-1,2-propanediolHCID 19358842HCID 19358842, compound

Product 1

HCID 19358861HCID 19358861, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

Prepared by the treatment of the product of Example 41b with 10 eq. of 3-amino-1,2-propanediol in N-methylpyrrolidinone at 100° C. for 18 hours. The mixture was poured on water to precipitate the product. The solids were filtered, washed with water, and then acetonitrile, to provide the title compound.

Workup

  1. additionThe mixture was poured on water
  2. customto precipitate the product
  3. filtrationThe solids were filtered
  4. washwashed with water

Sources & evidence

ORD record
ord-af2717f248bd4f7691b2140540cd3697
Source dataset
uspto-grants-2000_02
Patent number
US06025489

Reaction notes

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