Benzyl Bromide → HCID 15886851, compound

HRID 377582Notes

Reaction equation

HRID 377582 reaction equation
C([O-])([O-])=O.[K+].[K+].[CH2:7](Br)[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1.[CH3:15][C:16]1[N:24]=[C:23]2[C:19]([NH:20][CH:21]=[N:22]2)=[C:18]([NH2:25])[N:17]=1>CN(C=O)C.O>[CH2:7]([N:22]1[CH:21]=[N:20][C:19]2[C:23]1=[N:24][C:16]([CH3:15])=[N:17][C:18]=2[NH2:25])[C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1

Participants

6

Reactant 3

HCID 7498Benzyl BromideHCID 11430Potassium CarbonateHCID 150482-Methyladenine

Product 1

HCID 15886851HCID 15886851, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 6228DimethylformamideSolvent

Procedure

K2CO3 (0.26 g, 1.88 mmol) and benzyl bromide (0.5 ml, ca. 2 mmol) were added to a solution of 70 mg (0.47 mmol) of 2-methyladenine in a mixture of DMF (15 ml) and water (5 ml), and stirred at room temperature for 16 h. The solvent was evaporated under vacuum, and the residue was extracted by chloroform. The resulting organic layer was dried over MgSO4, and evaporated under vacuum. 9-Benzyl-2-methyladenine was obtained by the purification of the residue using column chromatography (CH2Cl2 :MeOH=50:1-30:1).

Workup

  1. customThe solvent was evaporated under vacuum
  2. extractionthe residue was extracted by chloroform
  3. dry with materialThe resulting organic layer was dried over MgSO4
  4. customevaporated under vacuum

Sources & evidence

ORD record
ord-7b92f9cab6ec4146bead4ee952af1155
Source dataset
uspto-grants-2000_02
Patent number
US06028076

Reaction notes

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