Potassium Carbonate → HCID 19356156, compound

HRID 377601Notes

Reaction equation

HRID 377601 reaction equation
F[C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[C:4]#[N:5].[OH:10][C:11]1[CH:12]=[C:13]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:14]=[CH:15][CH:16]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:4]([C:3]1[CH:6]=[CH:7][CH:8]=[CH:9][C:2]=1[O:10][C:11]1[CH:12]=[C:13]([CH2:17][C:18]([O:20][CH2:21][CH3:22])=[O:19])[CH:14]=[CH:15][CH:16]=1)#[N:5]

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 678552-FluorobenzonitrileHCID 572437Ethyl (3-Hydroxyphenyl)acetate

Product 1

HCID 19356156HCID 19356156, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Conditions

Temperature
160 °C

Procedure

4.23 g (35 mmol) of 2-fluorobenzonitrile, 6.3 g (35 mmol) of ethyl 3-hydroxyphenylacetate and 4.84 g of potassium carbonate (anhydrous) are dissolved in 40 ml of dimethylformamide and heated with stirring to a temperature of 160° C. Ethyl 3-(2-cyanophenoxy)-phenylacetate is formed takes place [sic]. The mixture is stirred for three hours while maintaining the temperature. The cooled reaction solution is treated with 150 ml of water and extracted with methyl t-butyl ether. The organic phase is separated off, washed with water and NaCl solution and dried. After distilling off the solvent, the product is obtained as an oil.

Workup

  1. temperatureheated

Sources & evidence

ORD record
ord-fc65cc8dfa434c1e870f8a8f313db0b9
Source dataset
uspto-grants-2000_02
Patent number
US06028080

Reaction notes

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