Tert-Butyl nitrite → HCID 21188131, compound

HRID 377646Notes

Reaction equation

HRID 377646 reaction equation
[C:1]([C:4]1[C:5]([C:22]#[N:23])=[N:6][N:7]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:12][C:11]=2[Cl:21])[C:8]=1N)(=[O:3])[CH3:2].C(ON=O)(C)(C)C>O1CCCC1>[C:1]([C:4]1[C:5]([C:22]#[N:23])=[N:6][N:7]([C:10]2[C:15]([Cl:16])=[CH:14][C:13]([C:17]([F:20])([F:19])[F:18])=[CH:12][C:11]=2[Cl:21])[CH:8]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 10906Tert-Butyl nitriteHCID 21188137HCID 21188137, compound

Product 1

HCID 21188131HCID 21188131, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

To a stirred solution of 4-acetyl-5-amino-3-cyano-1-(2,6-dichloro-4-trifluoromethylphenyl)pyrazole (0.4 g) in tetrahydrofuran (2 ml) was added dropwise t-butylnitrite (0.0262 ml). The mixture was heated under reflux for 30 minutes. The reaction mixture was applied to a silica gel (1 g) column and eluted with tetrahydrofuran to provide the title compound as white solid, m.p. 166-168° C.

Workup

  1. temperatureThe mixture was heated
  2. temperatureunder reflux for 30 minutes
  3. washeluted with tetrahydrofuran

Sources & evidence

ORD record
ord-1dab29638a8d4b1eb6cf4d85d855ce53
Source dataset
uspto-grants-2000_02
Patent number
US06028096

Reaction notes

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