Oxalyl chloride → HCID 86755157, compound

HRID 377746Notes

Reaction equation

HRID 377746 reaction equation
[CH3:1][S:2][C:3]1[CH:26]=[CH:25][C:6](/[CH:7]=[C:8]2/[C:9]([CH3:24])=[C:10]([CH2:20][C:21](O)=[O:22])[C:11]3[C:16]/2=[CH:15][CH:14]=[C:13]([N:17]([CH3:19])[CH3:18])[CH:12]=3)=[CH:5][CH:4]=1.C(Cl)(=O)C([Cl:30])=O>C1COCC1>[CH3:1][S:2][C:3]1[CH:26]=[CH:25][C:6](/[CH:7]=[C:8]2/[C:9]([CH3:24])=[C:10]([CH2:20][C:21]([Cl:30])=[O:22])[C:11]3[C:16]/2=[CH:15][CH:14]=[C:13]([N:17]([CH3:19])[CH3:18])[CH:12]=3)=[CH:5][CH:4]=1

Participants

4

Reactant 2

HCID 65578Oxalyl chlorideHCID 70289119HCID 70289119, compound

Product 1

HCID 86755157HCID 86755157, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

(Z)-1-(p-methylthiobenzylidene)-5-dimethylamino-2-methyl-3-indenylacetic acid (70 mmol) in THF (500 ml) is allowed to react with oxalylchloride (2 M in CH2Cl2 ; 70 mmol) under reflux conditions (24 hours). The solvent is evaporated to yield the title compound, which is used as such in the next step.

Workup

  1. customThe solvent is evaporated

Sources & evidence

ORD record
ord-8ddbd1becdaa4d3e954d8d4dfd4e0a54
Source dataset
uspto-grants-2000_02
Patent number
US06028116

Reaction notes

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