Water → Phenyl N-(2-hydroxy-4,5-dimethylphenyl)carbamate

HRID 377938Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 377938
[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH2:6])=[C:4]([OH:10])[CH:3]=1.Cl[C:12]([O:14][C:15]1[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=1)=[O:13].O>C(Cl)Cl>[CH3:1][C:2]1[C:8]([CH3:9])=[CH:7][C:5]([NH:6][C:12](=[O:13])[O:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[C:4]([OH:10])[CH:3]=1

Komponenten

5

Edukt 3

HCID 962WaterHCID 15891Phenyl chloroformateHCID 810992-Amino-4,5-dimethylphenol

Produkt 1

HCID 19356987Phenyl N-(2-hydroxy-4,5-dimethylphenyl)carbamateAusbeute 92 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To 4,5-dimethyl-2-hydroxyaniline(6.80 g, 0.05 mole), methylene chloride(100 ml) was added and then phenyl chloroformate(8.0 g, 0.05 mole) was added slowly. After stirring for 2 hours, addition of water(150 ml), extraction with methylene chloride and column chromatography gave the titled compound.

Quellen und Nachweise

ORD-Eintrag
ord-38a07a32ca0e4fe0b454bd7ab4861dd0
Quelldatensatz
uspto-grants-2000_02
Patentnummer
US06028195

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