Pyridine → 3-Thiophenecarboxamide,N-ethyl-

HRID 378038Notes

Reaction equation

HRID 378038 reaction equation
[S:1]1[CH:5]=[CH:4][C:3]([C:6]([OH:8])=O)=[CH:2]1.S(Cl)(Cl)=O.[N:13]1C=CC=[CH:15][CH:14]=1.Cl.C(N)C>CN(C=O)C.C1(C)C=CC=CC=1.C(Cl)Cl>[CH2:14]([NH:13][C:6]([C:3]1[CH:4]=[CH:5][S:1][CH:2]=1)=[O:8])[CH3:15]

Participants

8

Reactant 4

HCID 1049PyridineHCID 6918Thiophene-3-carboxylic acidHCID 11198Ethylamine hydrochlorideHCID 24386Thionyl Chloride

Product 1

HCID 154523283-Thiophenecarboxamide,N-ethyl-Yield 76%

Reagents, catalysts & solvents 3

HCID 6228DimethylformamideCatalystHCID 1140TolueneSolventHCID 6344DichloromethaneSolvent

Procedure

A mixture of 3-thiophenecarboxylic acid (20 g, 178 mmol), thionyl chloride (30 mL), and DMF (5 drops) was stirred overnight, then was concentrated under vacuum and stripped several times from toluene to remove all traces of excess thionyl chloride. Pyridine (31.64 g, 400 mmol) was added dropwise to a mixture of this acid chloride and ethylamine hydrochloride in toluene (5 mL) and CH2Cl2 (50 mL). After stirring for 1 h, the reaction was washed with 10% aq HCl followed with water, then was dried (MgSO4), concentrated, and crystallized from ethyl acetate/hexanes to give 14.9 g of N-ethyl-3-thiophenecarboxamide as a tan solid, a 76% yield. m.p. 115°-117° C.

Workup

  1. concentrationwas concentrated under vacuum
  2. customto remove all traces of excess thionyl chloride
  3. stirringAfter stirring for 1 h
  4. washthe reaction was washed with 10% aq HCl
  5. dry with materialwas dried (MgSO4)
  6. concentrationconcentrated
  7. customcrystallized from ethyl acetate/hexanes

Sources & evidence

ORD record
ord-4696cd16887d40c1ba41d8746eca21a0
Source dataset
uspto-grants-2000_02
Patent number
US06028101

Reaction notes

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