反应详情

To 3-pyridine carboxaldehyde (300 ml) in 2-propanol (3 liters) was added ammonium acetate (297 g) followed by malonic acid (398 g). The reaction mixture was stirred at reflux for 5 hours. The precipitate was filtered while hot and washed with hot isopropanol (2 liters). The resulting white solid was then dried to yield DL-3-amino-3-(3-pyridyl)propionic acid (220 g) as a white solid.

1. temperatureat reflux for 5 hours
2. filtrationThe precipitate was filtered while hot and
3. washwashed with hot isopropanol (2 liters)
4. customThe resulting white solid was then dried