Water → 5-(Aminomethyl)picolinonitrile

HRID 378316Notes

Reaction equation

HRID 378316 reaction equation
[C:1]([C:3]1[N:8]=[CH:7][C:6]([CH2:9][N:10]=[N+]=[N-])=[CH:5][CH:4]=1)#[N:2].O.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1>C1COCC1>[C:1]([C:3]1[N:8]=[CH:7][C:6]([CH2:9][NH2:10])=[CH:5][CH:4]=1)#[N:2]

Participants

5

Reactant 3

HCID 962WaterHCID 11776TriphenylphosphineHCID 219046275-(Azidomethyl)pyridine-2-carbonitrile

Product 1

HCID 113557155-(Aminomethyl)picolinonitrile

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

The compound obtained in (a) was dissolved in 45 ml of THF and 1.2 ml of water and, while stirring, 11.2 g of triphenylphosphine were added in portions. The reaction mixture was left to stand at RT overnight.

Workup

  1. waitThe reaction mixture was left

Sources & evidence

ORD record
ord-fb628f809a2147b79c012191bce5f78c
Source dataset
uspto-grants-2000_02
Patent number
US06030972

Reaction notes

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