反应详情

To 10.4 g of ethyl acetoacetate were added 15 g of 1,2-dibromoethane, 23 g of potassium carbonate, and 150 ml of N,N-dimethylformamide (DMF), and the mixture was stirred at room temperature for 2 days. Any insoluble matter was removed by filtration, and the filtrate was evaporated to dryness under reduced pressure. To the residue was added water, and the mixture was extracted with chloroform. The chloroform extract was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The resulting pale yellow oily substance was subjected to distillation under reduced pressure to obtain 7.5 g of ethyl 1-acetyl-1-cyclopropanecarboxylate having a boiling point of 70 to 71° C./2 to 3 mmHg.

1. customAny insoluble matter was removed by filtration
2. customthe filtrate was evaporated to dryness under reduced pressure
3. additionTo the residue was added water
4. extractionthe mixture was extracted with chloroform
5. extractionThe chloroform extract
6. dry with materialwas dried over anhydrous sodium sulfate
7. customthe solvent was removed under reduced pressure
8. distillationThe resulting pale yellow oily substance was subjected to distillation under reduced pressure