4-Methylmorpholine → HCID 56633503, compound

HRID 378675Notes

Reaction equation

HRID 378675 reaction equation
[CH2:1]([O:8][C:9]1[CH:14]=[CH:13][C:12]([C:15]2[C:16](=[O:31])[N:17]3[C:22](=[C:23]([C:25]([OH:27])=O)[CH:24]=2)[C:21]2[S:28][CH:29]=[CH:30][C:20]=2[CH:19]=[CH:18]3)=[CH:11][CH:10]=1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.C(N(C[C:38]1[CH:45]=[CH:44][C:41]([CH2:42][NH2:43])=[CH:40][CH:39]=1)CC)C.C[N:47]1[CH2:52][CH2:51]O[CH2:49][CH2:48]1.ON1C2C=CC=CC=2N=N1.Cl.CN(C)CCCN=C=NCC>CN(C)C=O>[CH2:48]([N:47]([CH2:52][CH3:51])[C:38]1[CH:39]=[CH:40][C:41]([CH2:42][NH:43][C:25]([C:23]2[CH:24]=[C:15]([C:12]3[CH:13]=[CH:14][C:9]([O:8][CH2:1][C:2]4[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=4)=[CH:10][CH:11]=3)[C:16](=[O:31])[N:17]3[C:22]=2[C:21]2[S:28][CH:29]=[CH:30][C:20]=2[CH:19]=[CH:18]3)=[O:27])=[CH:44][CH:45]=1)[CH3:49]

Participants

7

Reactant 5

HCID 79724-MethylmorpholineHCID 757711-HydroxybenzotriazoleHCID 27239391,3-Propanediamine, N'-(ethylcarbonimidoyl)-N,N-dimethyl-, monohydrochlorideHCID 7130831N-[4-(aminomethyl)benzyl]-N,N-diethylamineHCID 193536298-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid

Product 1

HCID 56633503HCID 56633503, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

From 8-[p-(benzyloxy)phenyl]-7-oxo-7H-thieno[2,3-a]quinolizine-10-carboxylic acid with 4-diethylaminomethyl-benzylamine, N-methyl-morpholine, 1-hydroxybenzotriazole and N-(3-dimethylaminopropyl)-N'-ethyl-carbodiimide hydrochloride in dimethylformamide.

Sources & evidence

ORD record
ord-62a3ca06b4a344c1a5390cb14e4aa766
Source dataset
uspto-grants-2000_02
Patent number
US06030984

Reaction notes

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